mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency
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چکیده
منابع مشابه
Ellagic acid improves hyperalgesia and cognitive deficiency in 6-hydroxidopamine induced rat model of Parkinson’s disease
Objective(s):Parkinson's disease (PD) is known for motor impairments. But often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. Antioxidants have protective effect on free radical-induced neuronal damage in PD. To further address, we examined the effects of ellagic acid (EA) in a rat model of PD induced by 6-hyd...
متن کاملSix cases of citrin deficiency in Korea.
Citrin deficiency resulting from mutations of the SLC25A13 gene is associated with two major clinical phenotypes; neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) and adult-onset type 2 citrullinemia (CTLN2). In Korea, 6 cases of citrin deficiency were diagnosed based on biochemical and molecular findings. Four NICCD patients (2 boys and 2 girls) presented high citrulline l...
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Growth hormone has been implicated in the regulation of cardiovascular function and growth hormone deficiency (GHD) has been postulated to be one of the main factors responsible for the increased morbidity and mortality from cardiovascular disease in both young and older patients with childhood- and adulthood-onset GHD. Growth hormone also influences bone turnover and mineral deposition. Subjec...
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15 صفحه اولDeficiency in mTORC1-controlled C/EBPb-mRNA translation improves metabolic health in mice
The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of physiological adaptations in response to changes in nutrient supply. Major downstream targets of mTORC1 signalling are the mRNA translation regulators p70 ribosomal protein S6 kinase 1 (S6K1p70) and the 4E-binding proteins (4E-BPs). However, little is known about vertebrate mRNAs that are specifically controlled by m...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2019
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2019.04.017